Immunodiagnosis in cutaneous T cell lymphoma: how does gene expression of the variable region of the T cell receptor fit into the diagnostic and pathophysiological picture of T cell neoplasia.

نویسندگان

  • D P Fivenson
  • B J Nickoloff
چکیده

M y c o s i s fiinge)idcs ( M F ) is a c u t a n e o u s ' I ' c-ell l y m p h o m a ( C ' l ' C l , ) w h i e h c a n p r e s e n t a s locali/.e-d i n ( l o l c n l pa l c lu s anel plac(uc-s l h a l c-linic-alK re-se-niblci n l l a n i m a t e i r y ekr i i i a loses , s u c h a s | ) s o r i a s i s , o r a s r a p i d l y preigrc-ssivc luiiie)rs w i t h i n l i l l r a l i o n of l y m p h nocle-s a n d \'isce-ra (1 ) . Flui m m u n o l o g } ' of C r F C F h a s in\cilve-cl nuillil'ae-c-le-d sludie-s e)l ' 'F e-cll r e g t i l a l i o n . In lliis c-chlorial rc-\ie-w, wel ocus on ihelalc-sl a|)|:)lie-alioii of n e w tc-chnolony elcsigiie-el lo cxple i i t t h e s c i e u l i r i c a d v a n c e s r e l a l c d lo iluonte)ocMi)' e)l I cc-ll c l o n a l c -xpans ion in l i i i m a n d i s e a s e |)roce-ssc-s. In acKance-d M F case-s, s i n \ i \ a l h a s t;c-iie-iall\" b e e n | ) oo r (2 , 3 ) , Howe-vc-r, somerc-ports ha\Ts i igg e s l e d a c u r a t i v e p o t e n t i a l (dc-fiiic-d a s bc-iiig d i s c a s e fn-e e i g h t y e a r s aftc-r t rea ln ie -n l is disc-onlimic-d) in e-arly (Stage1) M F w i l h lo|)ic-al ni l roge-n mi i s la re l a i u l / e i r leila! sk in e-leclrein-be-ain ihe-rapy ( 2 8 ) , O l h e r s l ia\ere-porle-d eeimbine-d l u o d a l i l y a p pre iac lu-s w i t h c-nc-ouragiug rcs i i l l s iu ihce-aiK sla.^e-s e)l M F, b u l n o sii ;nilic-aul i m p r e n c-mc-iils lii overall survixal ( , ' ) l l ) . Despite thefailure of these largeraiidomize-cl trials lo eurellunia |ori l \ ol palic-nts, llupote-utial for cure in some jialicnls with c-arly Ml' ' provides greal impc-lus for cslabl is lung this diagnosis as early in ils elcve-lopnu-iU as possible-. I Ie)we-\-ei, a palie-iil c-ousiderecl lo lia\-cM I ' c:liiiically may ree|iiiremany years and liumcreius biopsic-s be-lc)rellucliannoslichistology is ree-e)gnizc-d at llulight niie-ic)se-e)|)icIcve-l (12). Fluprinciple obstacle is the light microscopic asscssme-nt of early C'FC.L in thediirc-rc-ntialion hy the pathe)logist ot llulyniplie)pre)hlcrati\-e F cells of M F from benign, reactixe F cells associate'd with iullaiiimateiry skill disease-. In an c-HoiI lo ovc-rconullicsc liniilalie)ns in ree-ognizing early MF, several diHerent technique-s, i iul i iding T cell rece»pte)r ('FCK) gene rearraiigc-nu-nt studies and immunophenolyp i i ig of F cell markers , have been proposed as useful tools available lo helj) the diagnosis of M F ( IS . 14), M o Ic-culai-basc-d lc-clinic|iics ha\caltc-mptcd to disce-rn a elcinal popuial ion of 'F cells that was not a])parent on |-e-\icvv ol routine lu-nialoxylin/eosin-slainc-d sections.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of Swimming Endurance Exercise on Cell Death and Nicotinic Acetylcholine Receptor Gene Expression in Brain of Rat: An Experimental Study of Alzheimer's Disease Model

Background and Objectives: Alzheimerchr('39')s disease (AD) is a neurodegenerative disease which is marked by impaired cholinergic function and decreased nicotinic acetylcholine receptor (nAChRs) density. nAChRs are important mediators of cholinergic signaling in modulation of learning and memory function. In Alzheimer hippocampus is particularly vulnerable to specific degenerative processes an...

متن کامل

Cutaneous lymphomas and pseudolymphomas: A ten-year study at Emam Reza and Omid hospitals in Mashhad, using immunohistochemical and new classification methods

Background: Cutaneous lymphomas are monoclonal neoplastic proliferations of immune cells most frequently T or B cells that infiltrates skin. Development of new diagnostic methods, particularly those for immunophenotyping, have substantially changed classification of these neoplasms. These reasons prompted us to perform this study. Objective: To re-classify cutaneous lymphomas and pseudoly...

متن کامل

Hypocalcemia Revealing an Enteropathy-Associated T-cell Lymphoma

Background: Neurofollicular hamartoma (NFH) is characterized histopathologically by fascicles of spindle cells that laterally delimited by hyperplastic folliculosebaceous units. It usually appears on face, near the nose or nasolabial fold. It does not manifest true neural differentiation and recently the term spindle cell predominant trichodiscoma (SCPT) has been used instead. Case Presentatio...

متن کامل

The Epigenetic Regulation of Blinatumomab Gene Expression: Tumor Cell-dependent T cell Response against Lymphoma Cells and Cytotoxic Activity

Conventional treatment for cancer such as surgical resection and chemotherapy can cause damage in cases with advanced cancers. Moreover, the identification of tumor-specific targets has great importance in T-cell therapies. For decades, T cell activity has been stimulated to improve anti-tumor activity. Bispecific antibodies have attracted strong interest from pharmaceutical companies, for thei...

متن کامل

Altered expression of cell cycle regulators in adult T-cell leukemia/lymphoma patients

Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is caused by human T-cell lymphotropic virus type-1 (HTLV-1).  HTLV-1 oncogenes can induce malignancy through controlled gene expression of cell cycle checkpoints in the host cell. HTLV-I genes play a pivotal role in overriding cell cycle checkpoints and deregulate cellular division. In this study, we aimed to determine and comp...

متن کامل

Immunophenotype evaluation of Non-Hodgkin’s lymphomas

Background: Non-Hodgkin’s lymphoma (NHLs) is known as a heterogeneous group of malignant lymphoproliferative disorders. NHLs are classified into B cell and T cell types. Immunophenotypical assessment of the biopsy specimens can help diagnose NHLs.    Methods: In this study, 77 patients with B cell and T cell lymphoma were selected from Shahid Sadoghi hospital during 2010 to 2...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of cutaneous pathology

دوره 19 1  شماره 

صفحات  -

تاریخ انتشار 1992